Description
Proven Innovation: Carboxymethylcellulose and Fibroblast Regeneration
The inclusion of carboxymethylcellulose in our formulation amplifies its anti-aging properties. This
polysaccharide increases overall efficacy, playing a crucial role in the regeneration process of fi-
broblasts, the cells responsible for the synthesis of collagen and elastin. The stimulating action on
cellular metabolism accelerates epidermal turnover, leading to smoother and more uniform skin,
significantly younger and more vital. Through this mechanism of action, carboxymethylcellulose is
configured as a key ingredient, elevating not only skin well-being, but also the overall tone of the
epidermis.
Visible Results: Accelerated Rejuvenation and Personalized Treatments
The innovative treatment, supported by a state-of-the-art patent, is designed to act quickly and
efficiently, aiming to improve skin elasticity and firmness while visibly reducing wrinkles. The organic
and personalized approach allows a rapid restructuring of epidermal and dermal tissues, restoring
the freshness and vitality of the face. In this context, BRILLANTE does not limit itself to treating the
signs of aging; represents a real revolution in the field of aesthetic medicine, redefining the stan-
dards for cell regeneration.
BRILLANTE: The New Paradigm for Aesthetic Medicine
In the growing panorama of dermatology and aesthetic medicine, BRILLANTE stands out for its
ability to combine science and innovation, offering an integrated and multidimensional approach
to skin rejuvenation. With the aim of setting new benchmarks in the treatment of skin problems, Dr.
Kazkaz stands as a pioneer of an era in which beauty is not only surface, but also and above all he-
alth and deep well-being. Our treatment is not only an option for those looking to combat the signs
of aging, but a conscious choice for those looking to invest in their skin health and quality of life.
Safety and High Standards
Patient safety is a top priority in our formulations. The choice to use sterile medical vials, produced
according to strict pharmaceutical standards, is aimed at guaranteeing a level of purity and quality
without compromise, allowing patients to enjoy the benefits of treatment in a safe and controlled
setting.
In addition, each stage of our production is subjected to scrupulous quality controls, with constant
monitoring of manufacturing conditions and raw materials used. This ensures that the final product
is not only effective, but also highly tolerated by the skin,
All our clinical treatments that is based on strong principles of safety and compliance with health
regulations, providing patients with an effective and reassuring skincare experience.
PRODUCED IN STERILE VIALS FOR MEDICAL USE. TOPICAL, MESOTHERAPEUTIC USE.
ACTIVE INGREDIENT AND MODE OF ACTION
HYALURONIC ACID 500mg – 5 PM
Hyaluronic acid is a natural polysaccharide found in abundance in the connective tissues and epidermal
layers of the skin. Essential for skin health, it plays a crucial role in regulating tissue elasticity, hydration and
repair.
BRILLANTE, with hyaluronic acid at 500mg with an advanced formulation with 5 molecular weights is desi-
gned to maximize therapeutic and sensory benefits, optimizing the interaction and more efficient distribution
of the active ingredient in the different layers of the skin, stimulating the regeneration of the Extracellular
Matrix
The Extracellular Matrix (ECM) is crucial for skin health and hyaluronic acid, by promoting the synthesis of
collagen and new connective tissue, contributes to its regeneration, giving tone and resistance to the skin,
essential for counteracting the signs of skin aging.
Differentiated Effects Based on Penetrative Depth
The formula of our hyaluronic acid uses various molecular weights (from HMW to LMW):
• Surface Layer: The high-weight fractions (HMW) act mainly at the epidermal level, forming a pro-
tective barrier. It maintains hydration and reduces trans-epidermal water loss (TEWL), counteracting
dryness and superficial dehydration.
• Mid Layers of the Dermis: Medium weight fractions (MMW) improve the biochemical functions of the
skin, enhancing collagen synthesis and improving skin structure and tone. This results in a healthier and
more vital appearance.
• Deep Layers: Low-weight fractions (LMW) penetrate the deeper layers of the dermis due to their small
size. These components not only improve deep hydration, but also stimulate self-repair and restoration
of the skin structure, helping to reduce wrinkles and more marked expression lines.
The exclusive 500mg formulation of HA represents a valid option for improving skin health, with a
scientific and multidimensional approach to address issues related to aging, dehydration and tissue
regeneration. Choosing a product with a diversified combination of molecular weights means optimi-
zing the benefits within a spectrum of action that involves the skin at various levels, ensuring visible and
lasting results.
SUCCINIC ACID
Succinic acid, a naturally occurring dicarboxylic acid, plays a crucial role in skin health due to its unique bio-
logical properties. It is known for its ability to stimulate fibroblasts, the cells responsible for producing suppor-
ting fibers in the extracellular matrix, such as collagen and elastin. This synthesis is essential for maintaining
the elasticity and firmness of the skin.
It is a powerful antioxidant that helps protect skin tissues from the deleterious effects of oxidative stress, whi-
ch can cause premature aging and cell damage. Its effectiveness in improving microcirculation contributes
to a better distribution of essential nutrients and active ingredients in the skin tissues, promoting healthier and
brighter skin.
Particularly useful in the management of rosacea, succinic acid exerts an anti-inflammatory action that
reduces the local inflammatory response, relieving the symptoms associated with this condition. In this way,
it not only promotes the aesthetic appearance of the skin, but also supports the overall dermatological well-
being.
RNA/DNA complex (POLYNUCLEOTIDES)
With a three-dimensional action, they have the ability to attack large amounts of water and strongly moi-
sturize the skin. In addition, they strongly stimulate fibroblasts and initiate a spectacular reconstruction of
collagen and elastin fibers and the regeneration of damaged tissues. Thanks to their antioxidant action, they
protect tissues from protein glycation and increase their resistance to ultraviolet radiation.
The RNA/DNA complex (POLYNUCLEOTIDES) contains hydrolyzed fractions of RNA and DNA. These hydrolyzed
fractions have a lower molecular weight than the non-hydrolyzed fractions with a high molecular weight. DNA
and RNA complexes, low molecular weight fractions known as nucleotides will help increase skin hydration
and nourishment to promote a revitalized complexion. A proper hydration routine can reduce the appearance
of aging and minimize the appearance of fine lines and wrinkles, while reducing the appearance of dull, dry,
glow-free skin.
The use of RNA/DNA complexes (polynucleotides) in Aesthetic Medicine represents a new valid frontier from
a medical point of view, as polynucleotides play crucial roles in fundamental biological processes, such as
cell repair and tissue regeneration.
Three-dimensional action and hydration
Polynucleotides exhibit a unique three-dimensional shape that allows them to interact with large amounts of
water, thus acting as intensive moisturizing agents. This helps to keep the skin hydrated, and creates a favo-
rable environment for cell repair. Improving skin elasticity, visibly reducing wrinkles and fine lines, the intensive
hydration process is crucial for overall skin health that acts as a barrier against pathogens and contributes to
the maintenance of electrolyte balance.
Fibroblast Stimulation and Tissue Regeneration
The stimulating action on fibroblasts is particularly relevant, as they are mainly responsible for the production
of collagen and elastin, two proteins essential for the structure and resilience of the skin. Stimulating their
activity leads to the reconstruction of the extracellular matrix, increasing firmness and reducing skin sagging.
In the medical field, the treatment of wounds and scars can benefit enormously from this property, as effecti-
ve activation of fibroblasts accelerates healing processes.
Antioxidant Action and Protection from Environmental Damage
The antioxidant protection provided by RNA/DNA complexes plays a crucial role in protecting the skin from oxi-
dative damage. Free radicals, responsible for skin aging and other diseases, can be neutralized thanks to this
property. Glycation, a process in which excess sugars bind to proteins, can lead to a loss of functionality and
structural power of proteins. The ability of polynucleotides to attenuate this process is crucial not only for the
beauty of the skin, but also for the prevention of diseases related to premature aging.
Nourishment and Revitalization of the Complexion
Hydrolyzed low molecular weight RNA and DNA fractions play a key role in providing nourishment to skin tis-
sues. These bioactive compounds can improve cell function, promoting healthy and revitalized skin. Healthy
skin is synonymous with better overall health, and can also positively influence mental health and psychoso-
cial well-being.
In summary, RNA/DNA (polynucleotide) complexes offer a number of benefits in a medical context aimed
at improving skin health and preventing age-related diseases. Integrating these principles into treatment
protocols represents an innovative and multifunctional approach to improving skin health and, consequently,
quality of life as a whole.
Recombinant Humanized Collagen. α1 chain of type I collagen R polypeptides
The 1 Chain of R polypeptides of type I Collagen represents a bioactive form of collagen that has shown
remarkable efficacy in promoting the skin’s self-regeneration processes. This supports the stimulation of fibro-
blasts, stimulating the production of new pro-collagen and type I elastin fibers, which are essential for main-
taining the architecture and structure of the skin.
Collagen supplementation not only helps to regenerate the existing one, but also creates a thickening effect
on the skin tissues, improving their texture and resistance. This is particularly important in clinical settings whe-
re the aim is to counteract the signs of aging, such as wrinkles and skin laxity.
In addition, collagen has potential systemic benefits, as it can positively affect skin hydration, reducing transe-
pidermal water loss and improving overall skin health. This synergy of actions makes collagen a valuable ally
in dermatological therapy and in the prevention of skin aging.
CARBOXYMETHYLCELLULOSE
Carboxymethylcellulose (CMC) is a polysaccharide of non-bacterial and non-animal origin that has gained
increasing attention in the field of medicine and pharmacology. Used as an excipient in numerous medicines,
this substance is essential to ensure the stability, bioavailability and efficacy of active ingredients, making it a
fundamental component in different formulations.
Clinical Applications
Dermatology and Aesthetic Medicine: CMC is increasingly used as a carrier for dermal fillers, thanks to its
viscoelastic properties. It not only improves the texture and volume of the skin, but also contributes to a signi-
ficant anti-aging effect. It represents a precious resource thanks to its biocompatible, anti-inflammatory and
preservation properties of the integrity of the extracellular matrix.
Biochemical properties
CMC exhibits important anti-inflammatory activity, making it useful in treating dermatological conditions and
modulating inflammatory responses. One of the most important aspects of CMC is its ability to inhibit the
enzyme hyaluronidase, which degrades endogenous hyaluronic acid (HA). Thanks to this inhibition, hyaluronic
acid continues to play a crucial role in regulating skin hydration and tissue repair, maintaining its activity in the
deep structures of the skin.
MMP
CMC has been shown to exert a protective effect against MMPs (Matrix Metalloproteinases), enzymes essential
for tissue turnover, which, however, can lead to excessive degradation of type I collagen and impairment of the
dermal structure if not properly modulated. CMC’s ability to slow down the action of MMPs helps preserve the
integrity of the extracellular matrix, which is essential for skin health and youthfulness.
Molecular weight
The molecular weight of CMC is a key factor influencing the therapeutic efficacy of formulations. Adequate
molecular weight balance is necessary to optimize rheological properties, while ensuring a controlled relea-
se of active ingredients and promoting skin absorption, where deep penetration is essential to maximize the
benefits of the treatment.
INTENDED USE: Product for Medical professional use. Use in microneedle mesotherapy, needle-free mesothe-
rapy, sonophoresis, iontophoresis and oxygen infusion treatments.
The box contains 5 vials of 6 ml.
POSOLOGY. ONE (1) APPLICATION EVERY 21 – 30 DAYS FOR FOUR (4) TIMES. REPEAT THE CYCLE TWO (2) THREE (3)
TIMES A YEAR
